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Pub-med
2006
Primary research papers
Bartek J, Mailand N, TOPping up ATR Activity. Cell. 2006 Mar 10;124(5):888-90. PMID: 16530035
Bartek J, Lukas J, Cell biology. The stress of finding NEMO. Science. 2006 Feb 24;311(5764):1110-1. No abstract available. PMID: 16497923 [PubMed - indexed for MEDLINE]
Mailand N, Diffley JF, CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell. 2005 Sep 23;122(6):915-26. PMID: 16153703 [PubMed - indexed for MEDLINE]
2005
Primary research papers
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol. 2005 Dec 4; [Epub ahead of print] PMID: 16327781 [PubMed - as supplied by publisher]
Bartkova, J., Horejsi, Z., Koed, K., Guldberg, P., Krämer, A., Sehested, M., Nesland, J., Lu-kas, C., Ørntoft, T., Lukas, J., and Bartek. J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870 (2005).
Bekker-Jensen, S., Lukas, C., Melander, F. Bartek J., and Lukas J. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are coordinated by Mdc1/NFBD1. J. Cell Biol., 170, 201-211 (2005).
Bartkova, J., Bakkenist, C. J., Rajpert-De Meyts, E., Skakkebaek, N. E., Sehested, M., Lukas, J., Kastan, M. B., and Bartek, J. ATM activation in normal human tissues and testicular can-cer. Cell Cycle, 4, 838-845 (2005).
Syljuåsen, R. G., Sørensen, C. S., Hansen, L. T., Lundin, C., Jonansson, F., Helleday, T., Se-hested, M., Lukas, J., and Bartek, J. Inhibition of the human Chk1 kinase causes increased initiation of DNA replication, DNA breakage, and ATR response. Mol. Cell Biol., 25, 3553-3562 (2005).
Groth, A., Quivy, J.-P., Ray-Gallet, D., Lukas, J., Bartek, J., and Almouzni, G. Human Asf1 regulates the flow of S-phase histones during replicational stress. Mol. Cell, 17, 301-311 (2005).
Sorensen, C.S., Hansen, L. T., Dziegielewski, J., Syljuasen, R. G., Lundin, C., Bartek, J., Hel-leday, T. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous re-combination repair. Nat Cell Biol. 7, 195-201 (2005).
Agner, J., Falck, J., Lukas, J., and Bartek, J. Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway. Exp. Cell Res., 302, 162-169 (2005).
Reviews Lukas, C., Bartek, J., and Lukas, J. Imaging of protein movement induced by chromosomal breakage: Tiny local lesions pose great global challenges. Chromosoma, in 114, 146-155 (2005)
Johanna Tommiska , Sheila Seal , Anthony Renwick , Rita Barfoot , Linda Baskcomb , Hiran Jayatilake , Jirina Bartkova, Jonna Tallila , Milja Kaare , Anitta Tamminen , Päivi Heikkilä , D. Gareth Evans , Diana Eccles , Breast Cancer Susceptibility Collaboration (UK), Kristiina Aittomäki , Carl Blomqvist, Jiri Bartek,, Michael R. Stratton, Heli Nevanlinna, Nazneen Rah-man. Evaluation of RAD50 in familial breast cancer predisposition
2001-2004
Primary research papers
Syljuåsen, R, G., Sørensen, C. S., Nylandsted, J., Lukas, C., Lukas, J., and Bartek, J. Chk1 inhibition by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing ra-diation (IR). Cancer Res., 64, 9035-9040 (2004).
Sørensen, C. S., Syljuåsen, R. G., Lukas, J., and Bartek, J. ATR, claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle, 3, 941-945 (2004).
Bartkova, J., Guldberg, P., Lukas, J., Ørntoft, T. F., and Bartek, J. Aberrations of the Chk2 tumour suppressor in human urinary bladder cancer. Oncogene, 23, 8545-8551 (2004).
Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J., and Lukas, J. Centrosome-associated Chk1 prevents premature activation of cyclin B/Cdk1 kinase. Nat. Cell. Biol., 6, 884-891 (2004).
Latella, L., Lukas, J., Simone, C., Puri, P. R., and Bartek, J. Differentiation-induced radio-resistance in muscle cells. Mol. Cell Biol., 24, 6350-6361 (2004).
Lukas, C., Melander, F., Stucki, M., Falck, J., Bekker-Jensen, S., Goldberg, M., Lerenthal, Y., Jackson, S. P., Bartek, J., and Lukas, J. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J. 23, 2674-2683 (2004).
Kilpivaara, O., Vahteristo, P., Falck, J., Syrjakoski, K., Eerola H., Easton, D., Bartkova, J., Lukas, J., Heikkila, P., Aittomaki K., Holli K., Blomquist, C., Kallioniemi, O.-P., Bartek, J, and Nevanlinna, H. The CHEK2 variant I157T is associated with increased breast cancer risk. Int. J. Cancer, 111, 543-547 (2004).
Melixetian, M., Ballabeni, A., Masiero, L., Zamponi, R., Bartek, J., Lukas, J., and Helin, K. Loss of geminin induces rereplication in the presence of functional p53. J. Cell Biol. 65, 473-482 (2004).
Horejsi, Z., Falck, J., Bakkenist, C., Kastan, M., Lukas, J., and Bartek, J. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses in ionizing radiation. Oncogene, 23, 3123-3128 (2004).Löffler, H., Worm, J., Lukas, J., and Bartek, J. Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene 22, 8063-8071 (2003).
Bartkova, J., Lukas, C., Sørensen, C.S., Rajpert-De Meyts, E., Skakkebaek, N.E., Lukas, J., and Bartek. J. Deregulation of the RB pathway in human testicular germ cell tumours. J. Pathol. 200, 149-156 (2003).
Gatei, M., Sloper, K., Sørensen, C., Syljuåsen, R., Falck., J., Hobson, K., Savage, K., Lukas, J., Zhou, B.-B., Bartek, J., and Khanna, K. K. ATM and Nbs1 dependent phosphorylation of Chk1 in S317 in response to IR. J. Biol. Chem. 278, 14806-14811 (2003).
Groth, A., Hansen, K., Nigg, E. A., Sillje, H. H. W., Lukas, J., and Bartek, J. Human Tousled like kinases are targeted by an ATM and Chk1 dependent DNA damage checkpoint. EMBO J. 22, 1676-1687 (2003).
Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Zhou, B.-B., Bartek, J., and Lukas, J. Chk1 regulates the S-phase checkpoint by coupling the physiologi-cal turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3, 247-258 (2003).
Lukas, C., Falck, J., Bartkova, J., Bartek, J., and Lukas, J. Distinct spatio-temporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5, 255-260 (2003).
Tedesco, D., Lukas, J., and Reed S.I. The pRb-related protein p130 is regulated by phos-phorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. Genes. Dev. 16, 2946-2957 (2002).
Mailand, N., Podtelejnikov, A.V., Groth, A., Mann, M., Bartek, J., and Lukas, J. Regulation of G2/M events by Cdc25A phosphatase through phosphorylation-dependent modulation of its stability. EMBO J. 21, 5921-5929 (2002).
Santoni-Rugiu, E., Duro, D., Farkas, T, Mathiasen, I, Jäättelä, Bartek, J., and Lukas, J. E2F activity is essential for survival of Myc-overexpressing human cancer cells. Oncogene 21, 6498-6509 (2002).
Jensen, S.S., Madsen, M.W., Lukas, J., Bartek, J., and Binderup, L. Sensitivity to growth sup-pression by 1-alpha, 25-dihydroxyvitamin D(3) among MCF-7 clones correlates with vitamin D receptor protein induction. J. Steroid Biochem. Mol. Biol. 81, 123-133 (2002).
Farkas, T., Hansen, K., Holm, K., Lukas, J., and Bartek, J. Distinct phosphorylation events regulate p130 and p107-mediated repression of E2F-4. J. Biol. Chem. 277, 26741-26752 (2002).
Hsu, J.Y., Reimann, J.D.R., Sørensen, C.S., Lukas, J., and Jackson, P. E2F-dependent accu-mulation of hEmi1 regulates S phase entry by inhibiting APCCdh1. Nat. Cell Biol. 4, 358-366 (2002).
Mailand, N., Lukas, C., Kaiser, B.K., Jackson, P.K., Bartek, J., and Lukas, J. Premature cen-trosome splitting and aberrant chromosome segregation induced by deregulated human Cdc14 phosphatase. Nat. Cell Biol. 4, 317-322 (2002).
Falck, J., Petrini J.H.J., Williams B.R., Lukas, J., and Bartek, J. The DNA damage intra-S-phase checkpoint is regulated by parallel pathwyas. Nat. Genet. 30, 290-294 (2002).
Bartkova, J., Falck, J., Rajpert-De Meyts, E., Skakkebæk, N.E., Lukas, J., and Bartek, J. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. On-cogene 20, 5897-5902 (2001).
Falck, J., Lukas, C., Protopopova, M., Lukas, J., Selivanova, G., and Bartek, J. Functional impact of concomitant alternative defects in the Chk2-p53 tumour suppressor pathway. On-cogene 20, 5503-5510 (2001).
Jensen, S. S., Madsen, M. W., Lukas, J., Binderup, L., and Bartek, J. Inhibitory effects of 1?,25-dihydroxyvitamin D3 on the G1-S phase controlling machinery. Mol. Endocrinol. 15, 1370-1380 (2001).
Lukas, C., Bartkova, J., Latella, L., Falck, J., Mailand, N., Schroeder, T., Sehested, M., Lu-kas, J., and Bartek, J. DNA damage-activated checkpoint kinase Chk2 is independent of pro-liferation or differentiation, yet correlates with tissue biology. Cancer Res. 61, 4990-4993 (2001).
Sørensen C. S., Lukas, C., Kramer, E. R., Peters, J.-M., Bartek, J., and Lukas, J. Conserved cyclin binding domain determines functional interplay between APC/Cdh1 and cyclin A/Cdk2 during the cell cycle progression. Mol. Cell Biol. 21, 3692-3703 (2001).
Staller, P., Peukert, K., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bartek, J., Massague, J., Hänel, F., and Eilers, M. Repression of p15ink4b expression by Myc via association with Miz-1. Nat. Cell Biol. 3, 392-399 (2001).
Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J. & Lukas, J. The Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
Hansen, K., Farkas, T., Lukas, J., Holm, K., Rönnstrand L., and Bartek, J. Phosphorylation-dependent and –independent functions of p130 cooperate to induce a sustained G1 arrest. EMBO J. 20, 422-432 (2001).
Reviews
Lukas, J., and Bartek, J. The heart of the cycle. Nature, 432, 564-567 (2004).
Krämer, A., Lukas, J., and Bartek, J. Checking out the centrosome. Cell Cycle, 3, 1390-1393 (2004).
Lukas, J., and Bartek, J. Watching the DNA repair ensemble dance. Cell, 118, 666-668 (2004).
Bartek, J., Lukas, C., and Lukas, J. Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol., 5, 792-805 (2004).
Lukas, J., Lukas, C., and Bartek, J. Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time. DNA Repair, 3, 997-1007 (2004).
Zhou, B.B., and Bartek, J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat. Rev. Cancer, 4, 216-25 (2004).
Kastan, M. B., and Bartek, J. Cell-cycle checkpoints and cancer. Nature, 432, 316-23 (2004).
Bartek, J., and Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429 (2003).
Bartek J., and Lukas J. Damage alert. Nature 421, 486-488 (2003).
Bartek J., Falck, J., and Lukas, J. Chk2 kinase – a busy messenger. Nat. Rev. Mol. Cell Biol. 2, 857-884 (2001).
Bartek, J., and Lukas, J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol. 13, 738-747 (2001).
Bartek, J., and Lukas, J. Order from destruction. Science 294, 66-67 (2001).
Bartek, J., and Lukas, J. Are all cancer genes equal?. Nature 411, 1001-1002 (2001).
Bartek, J., and Lukas, J. p27 destruction: Cks1 pulls the trigger. Nat. Cell Biol. 3, E95-E98 (2001).
Bartek, J., and Lukas, J. Pathways governing G1/S transition and their response to DNA dam-age. FEBS Letters 490, 117-122 (2001).
Selected publications until 2000
Primary research papers
Mailand, N., Falck, J., Lukas, C., Syljuåsen R., Welcker, M., Bartek, J., and Lukas, J. Rapid destruction of human cdc25A in response to DNA damage. Science 288, 1425-1429 (2000).
Lukas, C., Sørensen, C.S., Kramer, E., Santoni-Rugiu, E., Lindeneg, C., Peters, J.-M., Bartek, J., and Lukas, J. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrange-ment of the anaphase-promoting complex. Nature 401, 815-818 (1999).
Meraldi, P., Lukas, J., Fry, A.M., Bartek, J., and Nigg, E.A. Centrosome duplication in mam-malian somatic cells requires E2F and Cdk2/Cyclin A. Nat. Cell Biol. 1, 88-93 (1999).Lukas, J., Herzinger, T., Hansen, K., Moroni, M.K., Resnitzki, D., Helin, K., Reed, S., and Bartek, J. Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11, 1479-1492 (1997).
Sandig, V., Brand, K., Herwig, S., Lukas, J., Bartek, J., and Strauss, M. Adenovirally trans-ferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat. Med. 3, 313-320 (1997).
Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375, 503-506 (1995).
Lukas, J., Bartkova, J., Rohde, M., Strauss, M., and Bartek, J. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independently of cdk4 activity. Mol. Cell. Biol. 15, 2600-2611 (1995).
Lukas, J., Müller, H., Bartkova, J., Spitkovsky, D., Kjelruff, A. A., Jansen-Dürr, P., Strauss, M., and Bartek, J. DNA tumour virus oncoproteins and retinoblastoma gene mutations share the ability to releive the cell´s requirement for cyclin D1 function in G1. J. Cell Biol. 125, 625-638 (1994).
Baldin, V., Lukas, J., Marcote, M.J., Pagano, M., and Draetta, G. Cyclin D1 is a nuclear pro-tein required for cell cycle progression in G1. Genes Dev. 7, 812-821 (1993).
Reviews
Bartek, J., Bartkova, J., and Lukas, J. The retinoblastoma protein pathway in cell cycle con-trol and cancer. Exp. Cell Res. 237, 1-6 (1997).
Bartek, J., Bartkova, J., and Lukas, J. The retinoblastoma protein pathway and the restriction point. Curr. Op. Cell Biol. 8, 805-814 (1996).
Strauss, M., Lukas, J., and Bartek, J. Unrestricted cell cycling and cancer. Nat. Med. 1, 1245-1246 (1995).
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