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Bartek and Lukas laboratories study molecular mechanisms that regulate the mammalian cell division cycle and the ways these mechanisms are employed to preserve genome integrity.
Specifically, we are interested to elucidate the genome surveillance pathways (so called ‘check-points’) designed to coordinate the cell fate decisions (cell cycle arrest, DNA repair, programmed cell death) in cells exposed to various types of genotoxic stress. In addition to the broad spectrum of genetic and biochemical approaches, our longterm interest is development and application of real-time imaging assays enabling direct visualisation of the key molecular events behind the cellular response to DNA damage in living mammalian cells.
The key milestones in Bartek & Lukas research could be summarised as follows:
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Identifying the signalling pathway culminating at the destruction of the Cdc25A phosphatase as an early event initiating the cellular defence response to DNA damage.
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Elucidating the key spatiotemporal patterns of intranuclear protein redistribution activated by genotoxic stress and their dynamic assembly at the site of DNA strand breaks.
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Identifying the DNA damage response pathway as a powerful anticancer barrier activated in early human tumorigenesis
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