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Pub-med
To view the complete list of CCC publications, please click here. Publications directly supported by the Danish National Research Foundation are included.
2011
Primary research papers
Lukas C., Savic V., Bekker-Jensen S., Doil C., Neumann B., Sølvhøj Pedersen R., Grøfte M., Chan K.L., Hickson I.H., Bartek J. and Lukas J. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nature Cell Biol. 10. (Published online Feb. 2011). Kosar M., Bartkova J., Hubackova S., Hodny Z., Lukas J. and Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type and insult-dependent manner, and follow expression of p16ink4a. Cell Cycle.10, issue 3, (2011).
2011
Reviews
Bartek J., and Lukas J. Cyclin D1 Multitasks. Nature. 474, 171-172 (June 2011
2010
Primary research papers
Larsen, D.H, Poinsignon, C., Gudjonsson, T., Dinant, C., Payne, M.R., Hari, F.J., Rendtlew Danielsen, J.M., Menard, P., Christensen Sand, J., Stucki, M., Lukas, C., Bartek, J., Andersen, J.S., and Lukas, L. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J. Cell Biol. 10, 1083 (2010).
Bouwman, P., Aly, A., Escandell, J.M., Pieterse, M., Bartokova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., Haffty, B.G., Tommiska, J., Blomqvist, C., Drapkin, R., Adams, D.J., Nevanlinna, F., Bartek, J., Tarsounas, M., Ganesan, S. and Jonkers, J. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative BRCA-mutated breast cancers. Nat. Struc. & Mol. Biol. 17, 688-695 (2010).
Kirkegaard, T., Roth, A. G., Petersen, N. H., Mahalka, A. K., Olsen, O. D., Mollanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., Kinnunen, P. K., Nylandstedt, J., and Jäättelä, M. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal Pathology. Nature, 463, 549-553 (2010).
Petersen L., Hasvold G., Lukas J., Bartek J. and Syljuåsen R.G. p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors. Cell Prolif.43(4):365-71( 2010).
Novakova Z, Hubackova S, Kosar M, Janderova-Rossmeislova L, Dobrovolna J, Vasicova P, Vancurova M, Horejsi Z, Hozak P, Bartek J, and Hodny Z. Cytokine expression and signaling in drug- induced cellular senescence. Oncogene, 29, 273-284,(2010).
Bennetzen, M. V., Larsen, D. H., Bunkenborg, J., Bartek, J., Lukas, J., and Andersen, J. S. Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol. Cell. Proteomics, 9, 1314-1323 (2010).
Blazkova, H., Krejcikova, K., Moudry, P., Frisan, T., Hodny, Z., and Bartek, J. Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signaling. J. Cell. Mol. Med., 14, 357-367 (2010).
Bartkova, J., Hamerlik, P., Stockhausen, M., Ehrmann, J., Hlobilkova, A., Laursen, H., Kalita, O., Kolar, Z., Poulsen H. S., Broholm, H., Lukas, J., and Bartek, J. Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene, 29, 5095-5102 (2010).
Liontos, M., Velimezi, G., Pateras, I. S., Angelopoulou, R., Papavassiliou, A. G., Bartek, J., Gorgoulis, V. G. The roles of p27(Kip1) and DNA damage signaling in the chemotherapy-induced delayed cell cycle checkpoint. J. Cell. Mol. Med. [Epub ahead of print] (2010).
Strauss, R., Li, Z. Y., Liu, Y., Beyer, I., Persson, J., Sova, P., Möller, T., Pesonen, S., Hemminki, A., Drescher, C., Urban, C., Bartek, J., Lieber, A. Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One, e16186 (2011). 2010.
2010
Reviews
Bartek, J., Hamerlik, P. and Lukas, J. On the orgin of prostate fusion oncogenes. Nat. Gene. 42, 647-648. (2010).
Hodny Z., Mistrik M. and Bartek J. HERCulean giant orchestraues ubiquiitin-mediated signaling on damaged chromosomes. Cell Cycle. 3;9(7). (Apr 2010).
Petersen N.H., Kirkegaard T., Olsen O.D., and Jäättelä M. Connecting Hsp70, sphingolipid metabolism and lysosmal stability. Cell Cycle. ( June 2010).
Hodny Z., Hubackova S. and Bartek J. Cytokines shape chemotherapy-induced and 'bystander' senescence. Aging. 2(7);375-6. (Jul 2010).
Bartek J, Mistrik M. and Bartkova J. Long- distance inflammatory and genotoxic impact of cancer in vivo. Proc Natl Acad Sci USA. 07(42);17992-7. (Oct 19, 2010).
Groth-Pedersen L. and Jäättelä M. Combating aåoåtosis and multidrug resistant cancers by targeting lyosomes. Cancer Lett. (Jun 2010).
Medema R.H. and Jäättelä M. Cytoslic Fox01: alive and killling. Nat. Cell. Biol. 12(7):665-75. (Jul 2010).
Hoyer-Hansen M., Nordbrandt S.P. and Jäätelä. Autophagy as a basis for the heslth-promoting effects of vitamin D. Trends Mol. Med.16(7):295-302.(Jul 2010).
2009
Primary research papers
Liontos M., Niforou K., Velimezi G., Vougas K., Evangelou K., Apostolopoulou K., Vrtel R., Damalas A., Kontovazenitis P., Kotsinas A., Zoumpourlis V., Tsangaris G.T., Kittas C., Ginsberg D., Halazonetis T.D., Bartek J. and Gorgoulis V.G. Modulation of the E2F1-driven cancer cell fate by the DNA damage repoonse machinery and potential novel E2F1 targets in osteosarcomas.
Am J Pathol., 175, 376-91. (2009).
Jiang, H., Reinhardt, H. C., Bartkova J., Tommiska, J., Blomqvist, C., Nevanlinna, H., Bartek, J., Yaffe, M. B., and Hermann, M. T. The combined status of ATM and p53 link tumor development with therapeutic response. Gene. Dev., 23, 1895-1909 (2009).
Mistrik, M., Oplustilova, L., Lukas, J., and Bartek, J. Low-dose DNA damage and replications stress responses quantified by optimized automated single-cell image analysis. Cell Cycle, 8, 2592-2599 (2009).
Marteijn, J. A., Bekker-Jensen, S., Mailand, N., Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, J., and Vermeulen, W. Nucleotide excision repair induced H2A ubiquitylation is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J. Cell Biol.,186, 835-847 (2009).
Fugger, K., Mistrik, M., Rendtlew Danielsen J., Dinant, C., Falck, J., Bartek, J., Lukas, J., and Mailand, N. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. J. Cell Biol., 186, 655-663 (2009).
Bartkova J., Tommiska, J., Oplustilova, L., Aaltonen, K., Taminen, A., Heikkinen, T., Mistrik, M., Aittomäki, K., Blomqvist, C., Heikkilä, P., Lukas, J., Nevanlinna, H., and Bartek, J. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol. Onc., 2, 296-316 (2009).
Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, J., and Weitzman, M. D. Mislocalization of the MRN complex prevents ATR signalling during Adenovirus infection. EMBO J., 28, 652-662 (2009).
Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D.H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Luka, J. and Lukas, C. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435-446 (2009).
Faustrup, H., Bekker-Jensen, S., Bartek, J., Lukas, J., and Mailand, N. USP7 counteracts SCFbTrCP– but not APCCdh1–mediated proteolysis of Claspin. J. Cell Biol., 184, 13-19 (2009).
Rendtlew-Danielsen J., Larsen D.H., Bødtker-Schou K., Freire R., Falck J., Bartek J., and Lukas J. HCLK2 is required for activity of the DNA damage response kinase ATR. J. Biol. Chem. 282, 19638-19643. (2009).
Carson C.T., Orazio N.I., Lee D.V., Suh J., Bekker-Jensen S., Araujo F.D., Lakdawala S.S., Lilley C.E., Bartek J., Lukas L., and Weitzmann M. Mislocalization of the M-rN complex prevents ATR signaling during adenovirus infection. EMBO J. Advanced on line publication, February 2009.
2009
Reviews
Jackson, S.P. and Bartek, J. The DNA-damage response in human biology and disease. Nature, 461, 1070-1078 (2009).
Lukas, J., and Bartek, J. New tales of an old tail. Nature, 458,518-583 (2009).
2008
Primary research papers
Bartkova, J.,Tommiskab, J., Lenka Oplustilova, L., Aaltonen, K., Tamminen, A., Heikkinen, T., Martin, M., Aittoma, K., Blomqvist, C., Heikkila, P., Lukas, L., Nevanlinn,H. and Bartek, J. Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol. Onco., 206-316 (2008).
Fagerholm, R., Hofstetter, B., Tommiska, J., Vrtel, R., Aaltonen, K., Syrjäkoski, K.,Kallioniemi, A., Kilpivaara, O., Mannermaa, A., Kosma, V.-M., Uusitupa, M.,Eskelinen, M., Kataja, V., Aittomäki, K., von Smitten, K., Heikkilä, P., Lukas, J.,Holli, K., Bartkova, J., Blomqvist, C., Bartek, J., and Nevanlinna H.NAD(P)H:Quinone Oxidoreductase 1 (NQO1) c.609C>T Genotype (P187S) is a Strong Prognostic and Predictive Factor in Breast Cancer. Nat. Genet., 40, 844-853 (2008).
Tommiska, J., Bartkova, J., Heinonen, M., Hautala, L., Kilpivaara, O., Eerola, H., Aittomäki, K., Hofstetter, B., Lukas, J., Blomqvist, C., von Smitten, K., Ristimäki, A., Heikkilä, P., Bartek, J. and Nevanlinna, H. The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triplenegative breast cancer. Oncogene, 27, 2501-2506 (2008).
Melander, F., Bekker-Jensen, S., Falck, J., Bartek, J., Mailand, N., and Lukas, J. Phosphorylation of MDC1 by casein kinase 2 mediates retention of NBS1 at the DNA damage-modified chromatin. J. Cell Biol., 181, 213-226 (2008).
Hansen, C. A., Bartek, J., and Jensen, S. A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3. Cell Cycle, 7, 325-334 (2008).
2008
Reviews
Lukas, J., and Bartek, J. DNA damage: A histone mediator leaves the stage. Nat.Struct. Mol. Biol., 15, 430-432 (2008).
Bartek, J., Hodny, Z., and Lukas, J. Chemokine loops driving senescence. Nat. Cell Biol. 10. 887-889, (2008).
Halazonetis, T. D., Gorgoulis, V. G., and Bartek, J. An oncogene-induced DNA damage model for cancer development. Science, 319, 1352-1355 (2008).
2007
Primary research papers
Johansen, L.D., Naumanen, T., Knudsen, A., Westerlund, N., Gromova, I., Junttila, M.,Nielsen, C., Bøttzauw, T., Tolkovsky, A., Westermarck, J., Coffey, E., Jäättelä, M.,Kallunki, T. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton. J. Cell. Sci., 121, 854-864 (2007).
Olesen, U.H., Christensen, M.K., Björkling, F., Jäättelä, M., Jensen, P.B., Sehested,M.and Nielsen, S.J. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochim. Biophys. Acta, 367, 799-804 (2007).
Bekker-Jensen S., Fugger K., Rendtlew-Danielsen J., Gromova I., Sehested M., Celis J., Bartek, J., Lukas J., and Mailand N. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J. Biol. Chem. 282, 19638-19643. (2007).
Ostenfeld, M.S., Høyer-Hansen, M., Bastholm, L., Fehrenbacher, N., Olsen, O.D.,Puustinen, P., Kirkegaard-Sørensen, T., Nylandsted, J., Farkas, T. and Jäättelä, M. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotectiveautophagosome accumulation. Autophagy, 4, 487-499 (2007).
Groth A, Corpet A, Cook AJL, Roche D, Bartek J, Lukas J and Almouzmi, G. Regulations of replication fork progression through histome supply and demand. Science Dec 2007; vol. 318 no.5888 1928-1931.
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C and Lukas J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007 Nov 17. vol.131, 1-14.
Sartori A, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J and Jackson SP. Human CtIP promotes DNA end resection. Nature. Nov. 2007.450(7169):509-14.
Löffler H, Bochtler T, Fritz B, Tews B, Ho AD, Lukas J, Bartek J, and Krämer A. DNA damage-induced accumulation of centrosomal chk1 contributes to checkpoint function. Cell Cycle. Oct 2007;6:20, 2541-2548.
Ahmed EA, Van D, V, Barten A, Kal HB, Chen J, Lou Z,Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, and de Rooif DG. Differences in DNA double strand breaks repair in male germ cell types: Lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair vol.6 1243-1254 (Amst) 2007.
Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr.Opin.Cell Biol. 2007;19:238-45.
Bartkova J, Rajpert-De ME, Skakkebaek NE, Lukas J, Bartek J. DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy. Int.J.Androl 2007.
Bartkova J, Horej S, I, Sehested M, Nesland JM, Rajpert-De ME, Skakkebaek NE et al. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 2007.
Hoyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol. Cell, 25, 193-205 (2007).
Groth-Pedersen, L., Ostenfeld, M.S., Hoyer-Hansen, M., Nylandsted, J., and Jaattela, M. Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine. Cancer Res., 67, 2217-2225 (2007).
2007
Reviews
Bekker-Jensen S., Fugger K., Rendtlew-Danielsen J., Gromova I., Sehested M., Celis J., Bartek J., Lukas J., and Mailand N. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J.Bio.Chem. 282, 19638-19643 (2007).
Oren, M., and Bartek J. The sunny side of p53. Cell, 128, 826-828 (2007).
Bartek, J., Lukas, J., and Bartkova, J. DNA damage response as an anti-cancer barrier: Damage threshold and the concept of conditional haploinsufficiency’. Cell Cycle, 6,2344-2347 (2007).
Høyer-Hansen, M. and Jäättelä, M., AMP-activated protein kinase – a universal regultor of autophagy? Autophagy, 3, 381-383, (2007).
Daugaard, M., Rohde, M., and Jäättelä, M. The heat shock of protein 70 family: Highly Homologous proteins with overlapping and distinct functions. FEBS Lett., 581:37023710 (2007).
Høyer-Hansen, M. and Jäättelä, M. Connecting endoplasmstic reticulum stress to autophagy by unfolding protein response and calcium. Cell Death Diff., 14, 1575-1582, (2007).
2006
Primary research papers
Syljuasen, R., Jensen, S., Bartek, J., and Lukas, J. (2006). Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res., 66(21):10253-7.
Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., Vassiliou L.V., Kolettas E., Niforou K., Zoumpourlis V.C., Takaoka M., Nakagawa H., Tort F., Fugger K., Johansson F., Sehested M., Andersen C.L., Dyrskjot L., Orntoft T., Lukas J., Kittas C., Helleday T., Halazonetis T.D., Bartek J., Gorgoulis V.G. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 2006 Nov 30;444(7119):633-7.
Gyrd-Hansen M, Farkas T, Fehrenbacher N, Bastholm L, Høyer-Hansen M, Elling M, Wallach D, Flavell R, Kroemer G, Nylandsted J, Jäättelä M. Apoptosome-independent activation of lysosomal cell death pathway by caspase-9. Mol Cell Biol. 26,7880-7891 (2006).
Liu, S., Bekker-Jensen, S., Mailand, N., Lukas, C., Bartek, J., and Lukas, J. (2006). Claspin Operates Downstream of TopBP1 To Direct ATR Signaling Towards Chk1 Acrivation. Mol Cell Biol., 26, 6056-6064.
Mailand, N., Bekker-Jensen, S., Bartek, J., and Lukas, J. Destruction of Claspin by SCFbTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell, 23, 307-318 (2006).
Tort, F., Bartkova, J., Sehested, M., Ørntoft, T., Lukas J., and Bartek, J. RB-pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res., 66, 10258-10263 (2006).
Löffler, H., Rebacz, B., Ho, A. D., Lukas, J., Bartek, J., and Krämer A. Chk1-dependent regulation of Cdc25B activity functions to coordinate mitotic events. Cell Cycle, 5, (Epub ahead of print, Nov. 1).
Koutsami, M. K., et al. Centrosome abnormalities are frequently observed in non-small-cell lung cancer and are associated with aneuploidy and cyclin E overexpression. J. Pathol., 209, 512-521 (2006).
Shiromizu, T., Goto, H., Tomono, Y., Bartek, J., Totsukawa, G., Inoko, A. et al. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells, 11, 477-485 (2006).
Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter-Kochanek, K., Jansen-Dürr, P., et al. p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell, 5, 379-389 (2006).
Bekker-Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bartek, J., and Lukas, J. (2006). Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol., 173, 195-206.
Tommiska, J., Seal, S., Renwick, A., Barfoot, R., Baskcomb, L., Jayatilake, H., Bartkova, J., Tallila, J., Kaare, Milja., Tamminen, A., Heikkilä, P., Evans., G.D., Eccles, D., Aittomäki, K., Blomqvist, C., Bartek, Jiri., Stratton, M., Nevanlinna and H., Rahman, N. Evaluation of RAD50 in familial breast cancer predisposition. Int J. Cancer, 2006 Jun 1;118(11):2911-6.
2006
Reviews
Halazonetis, TD., and Bartek, J. (2006). DNA Damage Signaling Recruits the RNA Polymerase II Binding Protein Che-1 to the p53 Promoter. [In press].
Loffler, H., Lukas, J., Bartek, J. and Kramer, A. (2006). Structure mets function-Centrosomes, genome maintenance and the DNA damage response. Experimental Cell Research. 312, 2633-2640.
Bartek, J., and Lukas, J. Balancing life-or-death decisions. Science, 314, 261-262 (2006).
Nevanlinna, H., and Bartek, J. The CHEK2 gene and inherited breast cancer susceptibility. Oncogene, 25, 5912-5919 (2006).
Bartek, J., Microcephallin guards against small brains, genetic instability, and cancer. Cancer Cell, 10, 91-93 (2006).
Bartek J, Mailand N, TOPping up ATR Activity. Cell. 2006 Mar 10;124(5):888-90.
Bartek J, Lukas J, Cell biology. The stress of finding NEMO. Science. 2006 Feb 24;311(5764):1110-1.
Lukas, J., Bohr, VA. and Halazonetis, TD. Cellular responses to DNA damage: Current state or the field and review of the 52nd Benzon Symposium. Dna Repair (Amst). 5, 591-601.
2005
Primary research papers
Bartkova, J., Horejsi, Z., Koed, K., Guldberg, P., Krämer, A., Sehested, M., Nesland, J., Lukas, C., Ørntoft, T., Lukas, J., and Bartek. J. (2005). DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870. Bekker-Jensen, S., Lukas, C., Melander, F. Bartek J., and Lukas J. (2005). Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are coordinated by Mdc1/NFBD1. J. Cell Biol., 170, 201-211.
Bartkova, J, Bakkenist, CJ, Rajpert-De Meyts, E, Skakkebaek, NE, Sehested, M, Lukas, J, Kastan, M B, and Bartek, J. ATM activation in normal human tissues and testicular cancer. Cell Cycle, 4, 838-845 (2005).
Mailand N, Diffley JF, CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell. 2005 Sep 23;122(6):915-26.
2005
Reviews
Lukas, C, Bartek, J, and Lukas, J. Imaging of protein movement induced by chromosomal breakage: Tiny local lesions pose great global challenges. Chromosoma, in 114, 146-155 (2005).
Kroemer, G and Jäättelä, M Lysosomes and autophagy in cell death control. Nat Rev Cancer. 2005 Nov;5(11):886-97.
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