Cell Death and Metabolism

Cell Death and Metabolism

We have followed ideas on the existence of “hidden” cell death pathways in therapy-resistant cancer cells and were among the first to show their existence and potential in treating therapy-resistant cancers.

Our work is not limited to the molecular characterization of the alternative cell death pathways, but has also lead to the identification of new types of drug targets and pharmaceutical compounds that regulate lysosomal membrane integrity, lysosome-dependent migration, lipid metabolism, plasma membrane repair, autophagy and DNA damage response.

We focus on exploring the cancer-associated changes in the composition, trafficking and function of lysosomes and autophagosomes, cancer-relevant signaling pathways responsible for cross-communication between transformation, invasion, cell death and survival as well as mechanisms underlying resistance to current cancer therapies. 

Lysosomal Pathways

Read more about Marja Jäättelä's group

Lysosomal Pathways

Invasion and Signaling

Read more about Tuula Kallunki's group

Invasion and Signaling

Membrane Integrity

Read more about Jesper Nylandsted's group

Membrane Integrity

Membrane Systems Biology

Read more about Kenji Maeda's group

Membrane Systems Biology

 Lipidomics

Read more about Mesut Bilgin's group

Lipidomics