Membrane Integrity

Group leader: Jesper Nylandsted

Our research focuses on cell membrane repair mechanisms in cancer and other human disorders, and novel approaches to target cancer cells by compromising plasma membrane integrity.

For this purpose we study cancer-associated cell membrane repair mechanisms using molecular biology methods, advanced live-cell imaging and biophysical models.

Our goal is to reveal comprehensive mechanistic insight into the repair system and develop novel strategies to inhibit cell membrane repair for future cancer therapy.

Jesper Nylandsted

Jesper Nylandsted

The Membrane Integrity Group is headed by Associate Professor Jesper Nylandsted and has extensive expertise within molecular mechanisms of plasma membrane repair and cell death signaling in cancer cells.

The group is characterized by strong interdisciplinary research within cancer, membrane physics, and molecular biology with a core expertise in live-cell imaging techniques. We have frequent exchange of researchers and a high degree of international collaboration.

Five selected publications:

Boye, T. L., Maeda, K., Pezeshkian, W., Sonder, S. L., Häger, S. C., Gerke, V., Simonsen, A. C., Nylandsted, J.
Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.
Nat.Commun. 2017: 8(1), 1623

Jaiswal, J. K., Lauritzen, S. P., Scheffer, L., Sakaguchi, M., Bunkenborg, J., Simon, S. M., Kallunki, T., Jäättelä, M., Nylandsted, J.
S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.
Nat.Commun. 2014: 5, 3795

Kirkegaard, T., Roth, A. G., Petersen, N. H., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., Kinnunen, P. K., Nylandsted, J., Jäättelä, M.
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.
Nature 2010: 463(7280), 549-553

Nylandsted, J., Gyrd-Hansen, M., Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M., Jäättelä, M.
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
J.Exp.Med. 2004: 200(4), 425-435

Nylandsted, J., Rohde, M., Brand, K., Bastholm, L., Elling, F., Jäättelä, M.
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Proc.Natl.Acad.Sci.U.S.A 2000: 97(14), 7871-7876

ORCID:

Jesper Nylandsted

0000-0001-6474-5093