Computational Biology Laboratory

Group leader: Elena Papaleo

Computational Biology Laboratory

The Computational Biology Laboratory (CBL) works with a “multi-scale” computational approach to cancer biology.

In our research, we start from the analyses of high-throughput data of cancer patients or cellular cancer models to define key targets to analyze under the lens of computational structural biology, integrating experimental validation toward the goal of drug design on the most promising targets.

We are supported by funds from NovoNordisk, LEO and Benzon Foundations, The Danish Council for Independent Research and the PRACE initiative. We also have access to the Danish Supercomputing Center Computerome.

Elena Papaleo

Elena Papaleo

Elena Papaleo is the head of CBL. She has a solid background in bioinformatic, structural biology and biochemistry. She received her PhD in 2006 from the University of Milano-Bicocca and carried out post-doctoral research in different institutes and universities in Italy, Spain and Denmark.

Elena is also active as Academic or Section Editor for main open access journals such as PloS Computational Biology, PloS ONE, PeerJ, Frontiers in Molecular Biosciences.

Her research interests are mainly in the field of the molecular mechanisms related to cancer alterations in coding regions of genes, redox modifications and cancer-related intrinsically disordered proteins.

Five selected publications:

Gaining insights into cancer biology through exploration of the cancer secretome using proteomic and bioinformatic tools. Papaleo E, Gromova I, Gromov P. Expert Rev Proteomics 2017;14:1021-35 

MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1. Capizzi M, Strappazzon F, Cianfanelli V, Papaleo E, Cecconi F. Autophagy 2017; 13:554-566. 

The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer. Nygaard M, Terkelsen T, Vidas Olsen A, Sora V, Salamanca Viloria J, Rizza F, Bergstrand-Poulsen S, Di Marco M, Vistesen M, Tiberti M, Lambrughi M, Jäättelä M, Kallunki T, Papaleo E. Front Mol Biosci 2016; 3:78 

DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions. Lambrughi M, De Gioia L, Gervasio FL, Lindorff-Larsen K, Nussinov R, Urani C, Bruschi M, Papaleo E. Nucleic Acids Res. 2016;44:9096-9109 

The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery. Papaleo E, Saladino G, Lambrughi M, Lindorff-Larsen K, Gervasio FL, Nussinov R. Chem Rev. 2016 ;116: 6391-423

ORCID and other links:

Elena Papaleo

ORCID: 0000-0002-7376-5894