Computational Biology

Group leader: Elena Papaleo

Computational Biology Laboratory

The Computational Biology group (CBL) works with a “multi-scale” computational approach to cancer biology.

In our research, we start from the analyses of high-throughput data of cancer patients or cellular cancer models to define key targets to analyze under the lens of computational structural biology, integrating experimental validation toward the goal of drug design on the most promising targets.

We are supported by funds from NovoNordisk, The Danish Council for Independent Research, Carlsberg Distinguished Fellowship and the PRACE initiative. We also have access to the Danish Supercomputing Center Computerome.

Elena Papaleo

Elena Papaleo

Elena Papaleo is the head of CBL. She has a solid background in bioinformatics, structural biology and biochemistry. She received her PhD in 2006 from the University of Milano-Bicocca and carried out post-doctoral research in different institutes and universities in Italy, Spain and Denmark.

Elena is also active as Academic or Section Editor for main open access journals such as PloS Computational Biology, PloS ONE, PeerJ, Frontiers in Molecular Biosciences.

Her research interests are mainly in the field of the molecular mechanisms related to cancer alterations in coding regions of genes, redox modifications and cancer-related intrinsically disordered proteins.

Five selected publications:

Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dotsch, V., Brech, A., Frankel, L. B., Jaattela, M., Locatelli, F., Barisic, M., Andersen, J. S., Bekker-Jensen, S., Lund, A. H., Rogov, V. V., Papaleo, E., Lanzetti, L., De Zio, D., Cecconi, F.
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.
Nat.Commun. 2019: 10(1), 4176

Lucchetta, M., da Piedade, I, Mounir, M., Vabistsevits, M., Terkelsen, T., Papaleo, E.
Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response.
BMC.Cancer 2019: 19(1), 824

Mounir, M., Lucchetta, M., Silva, T. C., Olsen, C., Bontempi, G., Chen, X., Noushmehr, H., Colaprico, A., Papaleo, E.
New functionalities in the TCGAbiolinks package for the study and integration of cancer data from GDC and GTEx.
PLoS.Comput.Biol. 2019: 15(3), e1006701

Lambrughi, M., De Gioia, L., Gervasio, F. L., Lindorff-Larsen, K., Nussinov, R., Urani, C., Bruschi, M., Papaleo, E.
DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.
Nucleic Acids Res. 2016: 44(19), 9096-9109

Papaleo, E., Saladino, G., Lambrughi, M., Lindorff-Larsen, K., Gervasio, F. L., Nussinov, R.
The role of protein loops and linkers in conformational dynamics and allostery.
Chem.Rev. 2016: 116(11), 6391-6423

ORCID and other links:

Elena Papaleo

ORCID: 0000-0002-7376-5894

Researchgate