Group leader: Giuseppe Filomeni

Cancer is characterized by heterogeneous molecular mechanisms and signaling pathways, which are induced by adaptive responses to stressful conditions (e.g. oxidative stress) and lead to the selection of cells characterized by therapy resistance, capability to migrate and invade distant tissues. In this context, the main focus has been always directed to the characterization of new redox signaling pathways governing life and death of cancer cells, and to the identification of the molecular players responsible for that. In this scenario, Giuseppe Filomeni contributed to clarify the role of the mitogen activated protein kinase (MAPK) super family and the AMP-dependent protein kinase (AMPK) in the cytotoxicity of numerous redox-active molecules, such as natural-derived polyphenols and organo-sulfur compounds, or chemotherapeutics of new synthesis. 
 
Currently, his main interest is to study the role of S-nitrosylation - the post translational modification induced by nitric oxide – in human pathophysiology with special emphasis in cancer and aging, which is, indeed, one of the major risk factors in cancer development.   

After his PhD (2002), Giuseppe Filomeni worked at the Institute for Cancer Research “Regina Elena” (Rome, IT) and as postdoc at the University “G. D’Annunzio” (Chieti, IT). Once completed his post-doctoral education, he was appointed as “Young Researcher” within the program “Funding for Base Research Investments” of the Italian Ministry of University and Research, during which he was awarded the Young Investigator Award from the Society for Free Radical Research-Europe (SFRR-E), Lodz (PL). After this experience, he worked one year as fellow of “Italian Association for Cancer Research” (IT) and obtained the academic position as Researcher at the Department of Biology of Tor Vergata University, (Rome, IT). In 2010, he was appointed as Group Leader at the Research Center “IRCCS San Raffaele Pisana”, Rome, (IT) and, in 2013, he was recruited as Senior Scientist at DCRC, where he contributed to establish the Cell Stress and Survival Unit. Two years later, he was upgraded to Group Leader of the “Redox Signaling and Oxidative Stress” research group.

Invited/selected speaker in several International Conferences (e.g., Gordon Conference, EMBO workshops; SFRR-E Meeting), his expertise is requested by several International agencies for project evaluations. Guest Editor and Member of the Editorial Board of peer-reviewed International Journals (e.g., Antioxidants and Redox Signaling, Frontiers in Oncology, etc.), he organized the Symposium “Redox and Metabolic Signaling in Cancer” within the SFRR-E Annual Meeting and has been appointed to organize the “VIII Workshop on Nitric Oxide in Cancer and Beyond”, to be held at DCRC in 2022.

 


 

Group leader Giuseppe Filomeni
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Key Funding

Danish Cancer Society Scientific Committee

The Novo Nordisk Foundation