Research Groups

Anja Groth - Epigenome Replication and Maintenance

The Groth group investigates how chromatin structure and function are preserved during DNA replication with a particular focus on histone modifications and dynamics. The groups has developed a suite of tools to examine newly-replicated chromatin  (e.g. ChOR-seq, SCAR-seq, and Repli-ATAC) and has revealed roles of the replication machinary in epigenetic inheritance. They continue to explore how the epigenome remains stable over cell divisions, and how disrupted epigenetic memory influences cell fate and contributes to aging and cancer progression.

Niels Mailand - Genome Maintenance and Cancer Vulnerabilities

The Mailand group investigates the cellular machinery that safeguards genome integrity, a critical defense against cancer. 

Using cutting-edge CRISPR screening, proteomics, and imaging, the group explores processes such as histone biogenesis, post-translational modifications (SUMO, Ubiquitination) in DNA repair and cell cycle progression. This work also identifies synthetic lethal interactions to uncover cancer-specific vulnerabilities, paving the way for precision therapies.

Jakob Nilsson - Cell Signaling and Cell Cycle

The Nilsson group study protein phosphorylation and the role of phosphatases particularly in mitotic signaling pathways — processes often hijacked in cancer. 

As well as elucidating phosphatase substrate recognition, they bring EpiC their expertise to investigate epigenome maintenance through mitosis, by combining cutting-edge CRISPR screens with biochemical assays. This work provides insights into therapeutic strategies targeting deregulated signalling in tumors.

Nils Krietenstein - Genome Organization and Gene Regulation

The Krietenstein group uses and develops ultra-high-resolution 3D genomics technology to explore how the 3D folding of the genome influences gene expression, and, in turn, the epigenetic memory of cell identity. Understanding of how genome structure imparts functional regulation will shed light on its roles on the dysregulation that occurs in malignancy and disease. 

EpiC facilities

EpiC will host a number of platforms to support our cutting-edge technologies:

CRIPSR screening platform + OPS
Genomics platform[FJ1]

Affiliated EpiC Research groups

Kathleen Stewart-Morgan – Epigenome Roles in Gametogenesis

The Stewart-Morgan group is based at the Department of Cellular and Molecular Medicine, University of Copenhagen. They use mouse genetics, molecular cell biology and next-generation sequencing methods to uncover the roles of the epigenome in gametogenesis: a process of particularly dynamic epigenetic change.