Virus, Lifestyle and Genes

The backbone of our research is the establishment of large population-based cohorts with collection of information on lifestyle habits, and biological samples (e.g., cervical cell samples, blood samples) stored in large biobanks.

We aim at having a strong link to clinical and translational research, and an important part of our studies falls within the area of molecular biological and clinical epidemiology with most studies being multidisciplinary.

Examples of focus areas:

• Human papillomavirus (HPV) and cancer
• Screening and/or early detection of cancer
• Ovarian cancer
• Cancer and other morbidity among women with infertility problems and their children
• Gene-environment interactions in cancer development
• Childhood cancer

We are also engaged in pharmacoepidemiological cancer research with an initial focus on gynecological cancers, and HPV related cancers. 

Selected publications:

Verdoodt F, Dehlendorff C, Jäättelä M, Strauss R, Pottegard A, Hallas J, Friis S, Kjær SK: Antihistamines and ovarian cancer survival: nationwide cohort study and in vitro cell viability assay. J Natl Cancer Inst 2020;112(9):964-967

Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK: Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol 2019;20(1):145-158

Hargreave M, Mørch LS, Andersen KK, Winther JF, Schmiegelow K, Kjær SK: Maternal use of hormonal contraception and risk of childhood leukaemia: a nationwide, population-based cohort study. Lancet Oncol 2018;19(10):1307-1314

Wang Y, Li L, Douville C, Cohen JD, Yen TT, Kinde I, Sundfelt K, Kjær SK, Hruban RH, Shih IM, Wang TL, Kurman RJ, Springer S, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Tanner EJ, Angarita A, Lycke M, Jochumsen K, Afsari B, Danilova L, Levine DA, Jardon K, Zeng X, Arseneau J, Fu L, Diaz LA Jr., Karchin R, Tomasetti C, Kinzler KW, Vogelstein B, Fader AN, Gilbert L, Papadopoulos N: Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci Transl Med 2018;10(433):eaap8793

Rasmussen CL, Sand FL, Frederiksen MH, Andersen KK, Kjær SK: Does HPV status influence survival after vulvar cancer? Int J Cancer 2018;142(6):1158-1165

Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira Jr. ED, Ngan Y, Petersen LK, Lazcano-Ponce E, Pitisuttithum P, Restrepo JA, Stuart G, Woelber L, Yang YC, Cuzick J, Garland SM, Huh W, Kjær SK, Bautista OM, Chan IS, Chen J, Gesser R, Moeller E, Ritter M, Vuocolo S, Luxembourg A: A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. N Engl J Med 2015;372(8):711-723